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Data 2fimages 2fnvvqqrnjtku1uvihmam0 190402 s0 hassan ammar amyloidosis intro
02:34
Amyloidosis
Data 2fimages 2fy0crqz5rjcsvoly6clka 190402 s1 hassan ammar amyloid
06:35
Amyloid
Data 2fimages 2fp6ephgicqoyj8tbhijgx 190402 s2 hassan ammar pathophysiology and clinical features
11:36
Pathophysiology and Clinical Features
Data 2fimages 2fxoucqiscqsuh0n7o1wak 190402 s3 hassan ammar amyloid histology
06:43
Amyloid Histology
Data 2fimages 2fyiqvofwqs5qcsstku5rg 190402 s4 hassan ammar diagnosis
12:42
Diagnosis
Data 2fimages 2fpim5rgqh6nymvsyhhjlq 190402 s5 hassan ammar management
10:41
Management

Lecture´s Description

Dr. Ammar Hassan expansively touches all aspects of amyloidosis at sqadia.com. Starting off with properties of amyloid, formation and classification of amyloid also comes under debate. Then histology of amyloid and diagnosis of amyloid through various diagnostic approaches such as SAP scanning and laser micro-dissection system are also discussed. Lastly, management of amyloidosis is pursued.

Amyloid

Amyloid is an abnormal deposit of insoluble polymeric protein fibrils in tissues and organ. Physical nature of amyloid is elaborated diagrammatically. Chemical nature of amyloid illustrates that amyloid P component (5%) consists of  stacks of doughnut-shaped proteins and a glycosoamynoglycan gives positive reaction with iodine.

Pathophysiology and Clinical Features

Initially, Dr. Ammar Hassan talks about pathogenesis of amyloidosis and explains the mechanism of normal proteins when produced in abnormal numbers and production of normal amounts of mutant proteins. Then light is shed on formation of amyloid. Subsequently, classification of amyloidosis on the basis of generalised/systemic amyloidosis and localised amyloidosis is given.

Amyloid Histology

This section is about amyloid histology. At first, staining characteristics of amyloid are highlighted. With haematoxylin and eosin stains, histologic sections of amyloid appear as amorphous and eosinophilic. Appearance of amyloid with congo red stain is also elaborated by Dr. Ammar Hassan.

Diagnosis

Diagnosis is carried out on the basis of presence of amyloid, type of amyloid, and mutation type. Following this, indications for test are reported. Along with chemical testing, imaging techniques such as technetium scan and SAP scanning is also pursued. Organ biopsy and laser micro-dissection system is also considered.

Management

This section is initiated by comprehensively elaborating the approach to patient with the help of flowchart. Following this, prognosis is pursued. Dr. Ammar Hassan tells that prognosis with generalized amyloidosis is poor while AL amyloidosis have a median survival.

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