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Blood Coagulation and Heparin
In this lecture ´´Anticoagulants´´ are explained. Section one is about ´´Blood Coagulation and Heparin´´. Educator dives an introduction of blood coagulation. Then blood coagulation cascade is exhibited. After that indirect thrombin inhibitors are elaborated. Likewise, heparin is explained. Alongside its mechanism of action is illustrated. This is followed by monitoring of heparin effect. Next focus is on elucidation of ADRs, contraindications, and administration and dosage. In the end, reversal of heparin action is discussed by the educator.
Section two is about ‘’Coumarin Anticoagulants’’. Earlier in this section, warfarin and other coumarin anticoagulants are pursued. After that their chemistry and pharmacokinetics are elaborated. Then mechanism of action is exhibited. Toxicity is also explained by the educator. Furthermore, administration and dosage are elucidated. Drug interaction is discussed later on. In the end, reversal of warfarin action is explained.
Direct Thrombin and Factor Xa Inhibitors
Section three is about ‘’Direct Thrombin and Factor Xa Inhibitors’’. Educator begins by discussing oral direct factor Xa inhibitors. After that pharmacology is pursued. Then rivaroxaban is explained. This is followed by apixaban. Likewise, esoxaban is highlighted. Moreover, information is delivered about administration and dosage. Later on, reversal of action is discussed. Then direct thrombin inhibitors are highlighted. Following this, parenteral direct thrombin inhibitors are reported. Subsequently, oral direct thrombin inhibitor is explained. Next subject is the elucidation of dabigatran etexilate. Alongside, administration and dosage are discussed. Lastly, assessment and reversal of antithrombin drug effect is reported.
Fibrinolytic Drugs and Antiplatelet Agents
Section four is about ‘’Fibrinolytic Drugs and Antiplatelet Agents’’. At first, basic pharmacology of fibrinolytic drugs is pursued. Then streptokinase is discussed. This is followed by urokinase. After that indications and dosage is explained. Moving onward, educator gives classification of fibrinolytic agents. Likewise, antiplatelet agents are discussed. Following this, aspirin is explained. Then thienopyridines: ticlopidine, clopidogrel, and prasugrel comes under consideration. Aspirin resistance is also discussed in this section. Later on, blockade of platelet glycoprotein IIB/IIIA receptors is illustrated. In the end, additional antiplatelet-directed drugs are elaborated.
Drugs Used in Bleeding Disorders
Section five is about ‘’Drugs Used in Bleeding Disorders’’. Educator primarily focuses vitamin K. Then plasma fractions are reported. Afterwards, recombinant factor VIIA is explained. Following this, fibrinolytic inhibitors: aminocaproic acid are discussed. In the end, educator sheds light on aprotinin and activated protein C.