Cancer Cell Biology

by Shahid, Aqueel

Medicine

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Data 2fimages 2fwzzx11bthardtf4jcunn 180913 s0 shahid aqueel cancer cell biology intro
02:13
Cancer Cell Biology
Data 2fimages 2fsoxuphejquofi2x1ujjc 180913 s1 shahid aqueel introduction
11:36
Introduction
Data 2fimages 2f5lkjjohos2sda90x9kky 180913 s2 shahid aqueel cell cycle and kinetics
15:53
Cell Cycle and Kinetics
Data 2fimages 2f6bzhyxboqtukttjvdemf 180913 s3 shahid aqueel new drug development and therapeutic strategies
21:39
New Drug Development and Therapeutic Strategies
Data 2fimages 2fifxxlsdgqiez6wyazke3 180913 s4 shahid aqueel tumor angiogenesis
10:03
Tumor Angiogenesis
Data 2fimages 2fh2b7hkzsqsuayhdm18g0 180913 s5 shahid aqueel antigenic therapy and immune evasion
10:25
Antigenic Therapy and Immune Evasion

Lecture´s Description

Introduction
In this lecture ´´Cancer Cell Biology´´ are explained. Section one is about ´´ Introduction´´. In the beginning, educator gives information about cancer cell biology and tells about characterization of cancers. Then neoplasms nomenclature is elaborated. Subsequently, phenotypic characteristics of malignant cells are explained.


Cell Cycle and Kinetics
Section two is about ''Cell Cycle and Kinetics''. Educator’s first theme of discussion is cell cycle check points. This include elucidation of DNA damage checkpoint and oncogene checkpoint. After that cancer growth kinetics is illustrated graphically. This is followed by gompertzian kinetics. In the end, educator talks about signal transduction pathway in cancer cells.


New Drug Development and Therapeutic Strategies
Section three is about ''New Drug Development and Therapeutic Strategies''. Prime emphasis is on oncogene addiction and synthetic lethality. Then synthetic lethality is pursued. Following this, epigenetic influences on cancer gene transcription are highlighted. Moreover, apoptosis and other mechanisms of cell death are illustrated. Afterwards, metastasis is explained. Next, cancer stem cells are focused. Plasticity and resistance is elaborated later on. In the end, cancer metabolism is discussed by the educator.


Tumor Angiogenesis
Section four is about ''Tumor Angiogenesis''. Initially, tumor microenvironment is discussed. After that angiogenesis is explained. Alongside, molecular determinants of endothelial cell biology are elaborated. Following this, normalization of tumor blood vessels is elucidated.


Antigenic Therapy and Immune Evasion
Section five is about ''Antigenic Therapy and Immune Evasion''. Educator begins by explaining FDA approved molecularly targeted agents. Then antiangiogenic therapy is elucidated. Educator gives concluding comments on evasion of immune system by cancer.

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