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In this lecture ´´Cancer Cell Biology´´ are explained. Section one is about ´´ Introduction´´. In the beginning, educator gives information about cancer cell biology and tells about characterization of cancers. Then neoplasms nomenclature is elaborated. Subsequently, phenotypic characteristics of malignant cells are explained.
Cell Cycle and Kinetics
Section two is about ''Cell Cycle and Kinetics''. Educator’s first theme of discussion is cell cycle check points. This include elucidation of DNA damage checkpoint and oncogene checkpoint. After that cancer growth kinetics is illustrated graphically. This is followed by gompertzian kinetics. In the end, educator talks about signal transduction pathway in cancer cells.
New Drug Development and Therapeutic Strategies
Section three is about ''New Drug Development and Therapeutic Strategies''. Prime emphasis is on oncogene addiction and synthetic lethality. Then synthetic lethality is pursued. Following this, epigenetic influences on cancer gene transcription are highlighted. Moreover, apoptosis and other mechanisms of cell death are illustrated. Afterwards, metastasis is explained. Next, cancer stem cells are focused. Plasticity and resistance is elaborated later on. In the end, cancer metabolism is discussed by the educator.
Section four is about ''Tumor Angiogenesis''. Initially, tumor microenvironment is discussed. After that angiogenesis is explained. Alongside, molecular determinants of endothelial cell biology are elaborated. Following this, normalization of tumor blood vessels is elucidated.
Antigenic Therapy and Immune Evasion
Section five is about ''Antigenic Therapy and Immune Evasion''. Educator begins by explaining FDA approved molecularly targeted agents. Then antiangiogenic therapy is elucidated. Educator gives concluding comments on evasion of immune system by cancer.