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In this lecture ´´Cell Death´´ are explained. Section one is about ´´Apoptosis´´. Initially, educator gives definition and explains the process of apoptosis. After that significance of apoptosis is discussed. Educator tells that cells also die when they become damaged or infected. Then necrosis is pursued.
Extrinsic Apoptotic Pathway
Section two is about ''Extrinsic Apoptotic Pathway''. Educator begins by comprehensively explaining caspase mediated pathway. Caspases are intracellular proteases which cleave their target proteins at specific aspartic acids. Then receptor mediated extrinsic pathway is elaborated. The receptors are homotrimers and belong to the tumor necrosis factor (TNF) receptor family.
Intrinsic Apoptotic Pathways
Section three is about ''Intrinsic Apoptotic Pathways''. At first, intrinsic pathway is exhibited. Alongside, fluorescence micrographs of human cancer cells in culture are also presented. After that information about regulatory proteins controlling intrinsic pathways is delivered. Educator tells that Bcl2 proteins regulate the intrinsic pathway of apoptosis.
Section four is about ''Apoptosis Regulation''. Prime emphasis is on elucidation of inhibitors of apoptosis. Educator tells that inhibitors of apoptosis (IAPS) proteins were first identified in certain insect viruses (baculoviruses).
Section five is about ''Phagocytosis''. Firstly, introduction is given. Then role of phagocytes is pursued. Likewise, information about apoptosis & disease is given. Furthermore, educator illustrates the process of necrosis during ischemia/reperfusion.