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Integrins: Transmembrane Heterodimers
In this lecture ´´ Cell-Matrix Junctions ´´ are explained. Section one is about ‘‘Integrins: Transmembrane Heterodimers’’. In the beginning, relationship of cell and extracellular matrix is demonstrated. After that, types of matrix receptors or co-receptors are discussed. Moving on, its structure and properties are brought under consideration. The educator also talks about transmembrane heterodimers. In the end, actin linked cell matrix junctions are elucidated in detail.
Section two is about '' Integrin Defects''. In the start of this section, defects in β and α subunits are mentioned. Moving forward, leucocyte adhesion deficiency is highlighted. Glanzmann’s disease is described in the end of this section.
Section three is about '' Conformational Changes ''. Educator's first subject of discussion is inactive and active states. After that, the outside-in mechanism is demonstrated in detail. Inside-out mechanism is also focused in the end.
Integrins Forming Strong Adhesions
Section four is about ''Integrins Forming Strong Adhesions”. Initially, the educator discusses how integrins cluster to form strong adhesions. This section also explains the process of recruitment of scaffolding and signalling proteins. After that, the controlling of cell proliferation and survival is demonstrated. Lastly, anchorage dependence is focused by the educator.
Response to Mechanical Forces
Section five is about “Response to Mechanical Forces”. In this beginning of this section, Ras/MAP kinase pathway is thoroughly explained. The focal adhesion kinase activation is then reported. In the end, the educator sheds some light on the process of mechano-transduction.