Cell-Matrix Junctions

by Afridi, Maham

Cell Biology

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Data 2fimages 2flel7tdbxtd6ygl46sze0 180928 s0 afridi maham cell matrix junctions intro
05:44
Cell-Matrix Junctions
Data 2fimages 2fgotnd99tspa9ds7jv3er 180928 s1 afridi maham integrins transmembrane heterodimers
18:08
Integrins: Transmembrane Heterodimers
Data 2fimages 2fhsktnoj0scotvdqa78qj 180928 s2 afridi maham integrin defects
12:01
Integrin Defects
Data 2fimages 2f3bvuulotdmhlgj0qt94x 180928 s3 afridi maham conformational changes
13:11
Conformational Changes
Data 2fimages 2f1pzcgtm5tg6swxttz2c7 180928 s4 afridi maham integrins forming strong adhesions
10:01
Integrins Forming Strong Adhesions
Data 2fimages 2fx4ci6ovsrqkhz5n13ieq 180928 s5 afridi maham response to mechanical forces
15:16
Response to Mechanical Forces

Lecture´s Description

Integrins: Transmembrane Heterodimers
 In this lecture ´´ Cell-Matrix Junctions ´´ are explained. Section one is about ‘‘Integrins: Transmembrane Heterodimers’’. In the beginning, relationship of cell and extracellular matrix is demonstrated. After that, types of matrix receptors or co-receptors are discussed. Moving on, its structure and properties are brought under consideration. The educator also talks about transmembrane heterodimers. In the end, actin linked cell matrix junctions are elucidated in detail.


Integrin Defects
Section two is about '' Integrin Defects''. In the start of this section, defects in β and α subunits are mentioned. Moving forward, leucocyte adhesion deficiency is highlighted. Glanzmann’s disease is described in the end of this section.


Conformational Changes
Section three is about '' Conformational Changes ''. Educator's first subject of discussion is inactive and active states. After that, the outside-in mechanism is demonstrated in detail. Inside-out mechanism is also focused in the end.


Integrins Forming Strong Adhesions
Section four is about ''Integrins Forming Strong Adhesions.  Initially, the educator discusses how integrins cluster to form strong adhesions. This section also explains the process of recruitment of scaffolding and signalling proteins. After that, the controlling of cell proliferation and survival is demonstrated. Lastly, anchorage dependence is focused by the educator.


Response to Mechanical Forces
Section five is about “Response to Mechanical Forces”. In this beginning of this section, Ras/MAP kinase pathway is thoroughly explained. The focal adhesion kinase activation is then reported. In the end, the educator sheds some light on the process of mechano-transduction.

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