Citric Acid Cycle (MD)

Biochemistry

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Lecture´s Description

In this video lecture, educator introduces the concept and process of citric acid cycle

This process takes place in four stages. The most likely sites for regulations are the nonequilibrium reactions catalyzed citrate synthase, isocitrate dehydrogenase, and α-ketoglutarate dehydrogenase

Educator explains Citrate Synthase, Isocitrate Dehydrogenase, α-ketoglutarate Dehydrogenase and Succinate Dehydrogenase. Three reactions of the TCA cycle as well as PDH utilize NAD+ as co-factor.

Energetics and Substrate Level Phosphorylation step is described by different diagrams. Krebs cycle is amphibolically very important. TCA plays role in catabolism, anabolism, synthesis of amino acids, fatty acid synthesis, heme synthesis, purine and pyrimidine synthesis.

Mammals lack the enzymes for the net conversion of acetyl CoA into oxaloacetate or any other citric acid cycle intermediate. There are four anaplerotic reactions.

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