This sqadia.com medical video lecture is the elaboration of the clinical pharmacology of prostaglandins. Synthesis of PGs and its inhibition mechanism has been conversed about. Moreover, prostaglandins analogues, receptor binding and expression, Prostanoids degradation, pain, inflammation and immunity has been presented. Additionally, endocrine effects and effects on bone along with therapeutic abortion, cytoprotection and pulmonary hypertension has been delineated.
The key objective of this section is on the prostaglandins. Initially, their structure has been shed light upon. Additionally, their synthesis has also been comprehensively talked about. Moreover, the inhibition of the prostaglandins synthesis has also been highlighted. Conclusively, various prostaglandin analogues including PGE-1, PGI 2 and alpha and PGE 2 has been discussed.
Receptor Binding and Expression
Initially, pharmacological properties of prostaglandins have been shed light upon. Following this, various PG receptors and prostanoids degradation has been mentioned. Furthermore, cell signalling pathway and expression has been expansively elaborated.
Primarily, pharmacological effects on cardiovascular system has been delineated. Additionally, platelets along with inflammation and immunity has been explained. Subsequently, smooth muscles, uterus and GIT muscles have been conversed about. Despite this, gastric and intestinal secretions along with elaboration of kidney, CNS and pain has been brought under consideration. Conclusively, bone, COX1 and 2 and PGE 2 has been explicated.
In the beginning, inhibitors, antagonists and agonists have been reported. Following that, therapeutic abortion and pulmonary hypertension has been delineated. Glaucoma, gastric cytoprotection along with impotence has been elaborated in-detail.