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Drug and Toxin Induced Liver Diseases
In this lecture ´´Diseases of Liver - II´´ is explained. Section one is about ‘’Drug and Toxin Induced Liver Diseases’’. Educator starts this section by giving information about drug and toxin induced liver injury. After that patterns of injury are discussed. Then hepatotoxins are elaborated. Following this, common drugs causing liver damage are highlighted. Furthermore, mechanisms of liver injury are illustrated. Alongside, morphology and clinical features are reported. Drug induced steatosis is the next subject of discussion. Likewise, Reye’s syndrome is elucidated along with its morphology. Later on, acetaminophen induced hepatotoxicity comes under consideration. Educator also focuses isoniazid induced hepatotoxicity. Moving onward, drug mediated injury by minocycline is explained. Concluding comments are given on drug mediated injury by nitrofurantoin.
Inherited Metabolic Disease
Section two is about ''Inherited Metabolic Disease''. Initially, hereditary hemochromatosis is discussed. Then causes of hemochromatosis are explained. This is followed by pathophysiology, clinical features, and morphology respectively. Afterwards, Wilson disease is pursued. Next is the elucidation of pathogenesis, morphology, clinical features and pathology. Moreover, α 1-antitrypsin deficiency is explained in this part. Alongside, its clinical features and morphology is elaborated. Lastly, cause of α 1-antitrypsin deficiency are explained by the educator.
Circulatory Disorders of Liver
Section three is about ''Circulatory Disorders of Liver''. Educator's first theme of elucidation is hepatic circulatory disorders. After that light is shed on hepatic artery compromise. Subsequently, passive congestion is discussed. Following this, portal vein obstruction is explained. Then discussion continues on portal vein thrombosis. Moving onward, Budd-Chiari syndrome is pursued along with its causes. Thorough elaboration of sinusoidal obstruction syndrome is given by the educator. In the next slide its morphology is discussed. Portal hypertension is also covered in this part. Later on, pathogenesis is exhibited. Then effect of portal hypertension on organ systems is reported. Next focus is on ascites and its causes and clinical presentation. Educator demonstrates splenomegaly. After that comparative explanation on normal vs enlarged spleen is given. Causes are also explained. Then hepatorenal syndrome is elucidated. Educator also notifies about its clinical features. Later on, portopulmonary HTN is focused along with clinical features. Following this, hepatopulmonary syndrome comes under consideration. Furthermore, pathogenesis and clinical features are discussed lastly.
Section four is about ''Infectious Diseases''. At first, educator talks about infectious agents. After that liver abscess is pursued. Information about its pathogenesis is given. Its clinical features and morphology are also discussed. Then granulomatous disease is elaborated. Following this, categories and causes are explained. Likewise, clinical features and pathology is reported. Educator also notifies about parasitic infestations. In the next slide, amebiasis is elaborated. Thorough explanation on malaria is given. Visceral leishmaniasis is discussed later on. Moreover, ascariasis comes under consideration. Discussion continues on liver flukes. Subsequently, echinococcosis is elucidated in detail. Educator also covers leptospirosis in this part. In the end, liver lesions are explained.
Section five is about ''Tumors''. Prime emphasis is on Focal Nodular Hyperplasia. After that morphology and clinical features are reported. Then hepatic cysts are illustrated. Its clinical features and morphology are also discussed. Subsequently, cavernous hemangiomas are elaborated. Alongside its pathogenesis and clinical features are explained. Educator notify about Von Meyenburg Complexes. Later on information about hepatic adenoma is conveyed. Subsequently, pathogenesis is exhibited. Furthermore, hepatoblastoma and its pathogenesis is also covered in this part. Following this, hepatocellular carcinoma is pursued. Alongside, pathogenesis, morphology and clinical features are highlighted. Cholangiocarcinoma is the next subject of discussion. Finally, its pathogenesis, morphology and clinical features are pursued.