Drugs for Urologic Disorders


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Data 2fimages 2f0kyxe4sht3sl71xat4oo 190115 s0 afzal sidra drugs for urologic disorders intro
Drugs for Urologic Disorders
Data 2fimages 2fjqkgu3mwrlmcjm51dnfn 190115 s2 afzal sidra alprostadil and tadalafil
Phosphodiesterase-5 Inhibitors
Data 2fimages 2feozygtrtkybz9u16l8ba 190115 s3 afzal sidra alpha 1 adrenergic antagonists
Alpha-1-Adrenergic Antagonists
Data 2fimages 2f71luklxproy2xqbntakl 190115 s4 afzal sidra 5 alpha reductase inhibitors
5-Alpha Reductase Inhibitors

Lecture´s Description

Erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) are common urologic disorders in males. Four approved phosphodiesterase-5 inhibitors i.e. sildenafil, avanafil, vardenafil, tadalafil are effective in treating ED but differ in the duration of action and the effects of food on drug absorption.

Alprostadil is synthetic prostaglandin E1 (PGE1). In the penile tissue, PGE1 allows for relaxation of the smooth muscle in the corpus cavernosum. Alpha 1-adrenergic antagonists such as terazosin, alfuzosin are indicated for the treatment of BPH. 5-α reductase inhibitors take up to 12 months to relieve symptoms. It includes finasteride and dutasteride.

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