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This sqadia.com medical video lecture provides detailed explanation of free radicals. Starting off with the formation of free radicals, superoxide anion, Harber’s reaction, cytosolic oxidations, and methemoglobin formation, focus of medical students is shifted towards Free Radicals Scavengers in which Glutathione Peroxidase and Lipid Peroxidation comes under debate. Then antioxidants and free radical diseases are pursued.
Formation of Free Radicals
An uncharged molecule having an unpaired valency electron is known as free radical. Univalent reduction of molecular oxygen initiates the formation of free radicals. Then Proneness of oxygen to produce superoxide radical is pursued along with Superoxide Anion and Other Free Radicals in the Body. In Haber’s reaction, H2O2 react with Superoxide anion. Furthermore, Warda Naz talks about Role of Ceruloplasmin, Formation of Hydroperoxy Radical, and Other Free Radicals.
Cytosolic oxidations take place By autooxidisable FP dependent enzymes. Next, Univalent Oxidation comes under consideration. During methaemoglobin formation, Superoxide anion formation takes place. After that educator explains Cytosolic Hydroxylations through chemical equations. Lastly, Ionizing Radiation and Phagocytosis is pursued in this section.
Free Radicals Scavengers
This section is about Free Radicals Scavengers. At first, information about Superoxide Dismutase is given that its Function is protecting aerobic organisms against harms of O2–. Then Catalase is highlighted. Discussion continues on Glutathione Peroxidase along with Ferricytochrome. Moreover, Lipid Peroxidation is also delineated. Their Effect on Biomembranes is also considered.
Antioxidants are used for Controlling and reducing lipid peroxidation. Comprehensive elaboration is given on Naturally Occurring Antioxidants. There are Two classes of antioxidants according to their mode of action i.e. preventive antioxidants and Chain breaking antioxidants. Preventive Antioxidants Reduce rate of chain initiation. Chain Breaking Antioxidants Interfere with chain propagation.
Free Radical Diseases
Free radicals have important role in aging. Preterm babies are Vulnerable to free radicals. Diseases like Broncho-pulmonary dysplasia, Retinopathy of maturity are considered. In Rheumatoid Arthritis, drugs such as Corticosteroids & NSAIDs are given which Interfere with formation of free radicals Thus provides relief. After that Atheraosclerosis Vs Thrombosis is discussed.