This sqadia.com medical video lecture provides a detailed explanation of glycolipids. The prime focus of this lecture is cerebrosides, Gaucher’s disease, gangliosides, and Tay-Sachs disease. Additionally, comments are given on sulpholipids, metachromatic leukodystrophy, Fabry’s disease, and Krabbe’s disease. Lastly, amphipathic lipids and their orientation is pursued.
Cerebrosides are lipids present in the myelin sheaths of nerve in white matter of brain. Structurally, there is no glycerol, no phosphoric acid and no nitrogenous base in cerebrosides. Kerasin, cerebron, nervon, and oxynervon are types of cerebrosides. Then psychosine comes under consideration. Subsequently, Gaucher’s disease is discussed which is an inherited disorder of cerebrosides metabolism.
Highest concentrations of gangliosides are found in gray matter. Structure of gangliosides is composed of a long chain fatty acid, alcohol-sphingosine, and a carbohydrate moiety. Types of gangliosides are also highlighted with the help of diagram. Tay-Sachs disease is an autosomal recessive disorder in which accumulation of gangliosides in brain and nervous tissues takes place.
Sulpholipids are most abundant in white matter. Metachromatic leukodystrophy (MLD) is an inherited disorder in which sulfatide accumulates in various tissues. Next is the Fabry’s disease which is also an inherited disorder. Subsequently, Krabbe’s disease is discussed, an inherited disorder of lipid metabolism. Sidra Afzal has also enlightened the clinical manifestation and diagnosis of these disorders along with examples of sphingolipidoses.
Amphipathic lipids are lipids containing both polar and non-polar groups. Fatty acids, phospholipids (PL), bile salts, and to a lesser extent cholesterol contain “polar” groups. After that orientation of amphipathic lipids is elaborated in detail with the help of diagrammatic representation. Then uses of liposomes comes under consideration as they are used for gene transfer into vascular cells.