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The key objective of this sqadia.com medical video lecture is metabolism of purines. This V learning lecture emphasizes upon the purine synthesis, materials required for synthesis along with the purine synthesis pathway. Additionally, synthesis of purine nucleotides, salvage pathways along with the adenine and guanine nucleotide catabolism has been broadly explicated.
In the beginning of this section, structures of two purines i.e. adenine and guanine has been presented. Following this, biosynthesis of purines along with the sources of carbon and nitrogen of purines has been shed light upon. In the end, materials required for purine synthesis have been conversed about in-detail.
Purine Synthesis Pathway - I
Initially, formation of 5-phosphoribosyl-1-phosphate (PRPP) has been elaborated. Subsequently, formation of 5’-phosphoribosyl-1 amine (PRA), glycinamide ribotide (GAR) and formylglycinamide Ribotide (FGAR). Conclusively, the synthesis of a-N-formylglycinamidine ribotide and 5-aminoimidazole riboside (AIR) has been explained comprehensively.
Purine Synthesis Pathway - II
In the commencement of this section, 5-aminoimidazole-4-carboxylic acid ribotide has been mentioned in-detail. Following this, the mechanism along with the 5-aminoimidazole-n-succinyl carboxamide ribotide and 5-aminoimidazole-4-carboxamide ribotide has been explicated. In the end, the section has been summed up by conversing about 5-formamidoimidazole-4-carboxyamide ribotide and formation of inosinic acid (IMP).
Synthesis of Purine Nucleotides
The focal point of this section is synthesis of purine nucleotides. Primarily, formation of AMP from inosinic acid (IMP) has been expansively talked about. In the end, formation of GMP from inosinic acid (IMP) has been highlighted in-detail.
Salvage Pathways and Catabolism of Purines
Firstly, salvage pathways for purines and the regulation has been brought under discussion. In addition to this, two-step synthesis along with the catabolism of purines has been conversed about in-detail. In the end, adenine and guanine nucleotide catabolism has been elaborated.