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In this lecture ´´Microbial Genomics´´ are explained. Section one is about ´´DNA Sequencing´´. Initially, educator introduces sequencing methods. After that Maxam/Gilbert Chemical Sequencing is explained. Then Sanger Sequencing is elaborated. Educator also introduces this method as chain termination (Sanger) sequencing. After comprehensive elaboration of Sanger sequencing, fluorescent dyes are focused. Likewise, information is given about determining DNA sequences. Later on, next-generation DNA sequencing i.e. pyrosequencing is also covered in this section. Additionally, educator notify massively parallel DNA sequencing methodologies.
Section two is about ‘’Genome Sequencing’’. Educator begins by elucidating whole-genome shotgun sequencing. This is followed by approach-shotgun sequencing. After that single-cell genomic sequencing is pursued. Then discussion continues on bioinformatics.
Section three is about ‘’Functional Genomics’’. In the first few slides of this section Functional Genomics is elaborated. Then metabolic pathways and transport systems are discussed. Likewise, transcriptome analysis also comes under this part. transcriptome analysis-applications are highlighted later on. Concluding comments are given on hierarchical cluster analysis.
Section four is about ‘’Proteomics’’. Primary emphasis is on proteomics. In the next slide, mass spectrometry (MS) is discussed. Then probing DNA-protein interactions is covered by the educator. Systems biology is the last subject of discussion.
Comparative Genomics and Metagenomics
Section five is about ‘’Comparative Genomics and Metagenomics’’. Earlier in this section, comparative genomics is discussed. Then synteny is focused. Subsequently, pseudogenes are pursued. Metagenomics comes under consideration later on. Last part of this includes phylogenetic diversity.