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7yulcytcqp22v7cjmos4 180807 s0 abid abira mutations intro
Jagrg7fseytadscncoya 180807 s1 abid abira causes and nomenclature
Causes and Nomenclature
Gwxtyfaxrumsx0bhgpna 180807 s2 abid abira types
Fpyzsagt2cg41uhhcfaq 180807 s3 abid abira phenomena related to mutation
Phenomena Related to Mutation
H30ey4lus1sfmic4nf6t 180807 s4 abid abira terminology
Zczzujker4upfu39li3p 180807 s5 abid abira impact and clinical correlation
Impact and Clinical Correlation

Lecture´s Description

Causes and Nomenclature  

In this lecture ´´Mutations´´ are explained. Section one is about ´´Causes and Nomenclature´´. Educator begins by explaining mutation. After that genetically harmful agents are reported. Then information about mutagens is given. Following this, other causes of mutations are reported. Lastly, detailed discussion continues on nomenclature.


Section two is about ‘’Types’’. Initially, types of mutation are reported. Then point and frameshift mutation are discussed. Subsequently, synonymous and nonsynonymous mutations are explained. Afterwards, missense and nonsense mutation are focused. Furthermore, germinal versus somatic mutation is elaborated. In the end, pathogenic mutations and benign variants are elucidated.

Phenomena Related to Mutation

Section three is about ‘’Phenomena Related to Mutation’’. Earlier in this section polymorphism is elucidated. After that information about measuring mutation rate is given. Then spontaneous mutation is focused in which depurination, deamination, and tautomeric shifts are thoroughly discussed. Moving onward, mutations in noncoding DNA are pursued. In the end functional effects of mutations on protein is highlighted.


Section four is about ‘’Terminology’’. Educator discusses paternal age effect. Then genetic variability is considered. Next is the elucidation of frequency of mutations. After that Mutation frequency and rate is discussed. In the end, frequency of different types of mutations is exhibited.

Impact and Clinical Correlation

Section five is about ‘’Impact and Clinical Correlation’’. At first, impact of mutations is discussed. After that transposable elements are explained. Then information is delivered about DNA repair mechanism. Following this, educator talk about DNA repair mechanism and related disorders. Furthermore, DNA repair syndromes are elucidated. Then clinical correlation comes under consideration. This involves explanation of cystic fibrosis and Duchenne muscular dystrophy.

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