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Causes and Nomenclature
In this lecture ´´Mutations´´ are explained. Section one is about ´´Causes and Nomenclature´´. Educator begins by explaining mutation. After that genetically harmful agents are reported. Then information about mutagens is given. Following this, other causes of mutations are reported. Lastly, detailed discussion continues on nomenclature.
Section two is about ‘’Types’’. Initially, types of mutation are reported. Then point and frameshift mutation are discussed. Subsequently, synonymous and nonsynonymous mutations are explained. Afterwards, missense and nonsense mutation are focused. Furthermore, germinal versus somatic mutation is elaborated. In the end, pathogenic mutations and benign variants are elucidated.
Phenomena Related to Mutation
Section three is about ‘’Phenomena Related to Mutation’’. Earlier in this section polymorphism is elucidated. After that information about measuring mutation rate is given. Then spontaneous mutation is focused in which depurination, deamination, and tautomeric shifts are thoroughly discussed. Moving onward, mutations in noncoding DNA are pursued. In the end functional effects of mutations on protein is highlighted.
Section four is about ‘’Terminology’’. Educator discusses paternal age effect. Then genetic variability is considered. Next is the elucidation of frequency of mutations. After that Mutation frequency and rate is discussed. In the end, frequency of different types of mutations is exhibited.
Impact and Clinical Correlation
Section five is about ‘’Impact and Clinical Correlation’’. At first, impact of mutations is discussed. After that transposable elements are explained. Then information is delivered about DNA repair mechanism. Following this, educator talk about DNA repair mechanism and related disorders. Furthermore, DNA repair syndromes are elucidated. Then clinical correlation comes under consideration. This involves explanation of cystic fibrosis and Duchenne muscular dystrophy.