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Discovery and Synthesis
In this lecture ´´Nitric Oxide´´ is explained. Section one is about ‘‘Discovery and Synthesis’’. Educator starts this section by introducing nitric oxide. After that endothelial derived relaxing factor is explained. Then role of nitric oxide is highlighted. Discovery of endogenously generated NO is also elaborated in this part. Lastly, information about its synthesis is delivered.
Signaling and Mechanism of Action
Section two is about ''Signaling and Mechanism of Action''. In the beginning, educator talks about release and MOA. Then types of NOS are discussed. Subsequently, signaling mechanisms are exhibited. This is followed by metalloproteins. Later on, thiols are reported. Tyrosine nitration are thoroughly demonstrated. Lastly, educator notifies about inactivation.
Nitric Oxide Activators and Inhibitors
Section three is about ''Nitric Oxide Activators and Inhibitors''. Firstly, agents related to NO comes under consideration. After that nitric oxide activators are pursued. Then oxides of nitrogen are explained. Moreover, inhibitors of nitric oxide synthesis are illustrated.
Nitric Oxide Donors
Section four is about ''Nitric Oxide Donors''. Earlier in this section, overview of nitric oxide donors is given. After that organic nitrates are elaborated by the educator. Then organic nitrites are pursued. Following this, information about sodium nitroprusside is revealed. NO gas inhalation is discussed later on. In the end, educator talks about alternate strategies.
Section five is about ''Clinical Pharmacology''. Educator's first theme of elucidation in this part is vascular effects. This is followed by septic shock. Then infection and inflammation are discussed. Furthermore, their role in central nervous system is demonstrated. NO in peripheral nervous system is also explained.