Pathogen Invasion

Cell Biology

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Data 2fimages 2fht084tqor7os0pmvdekn 190419 s0 arfeen zain pathogen invasion intro
03:15
Pathogen Invasion
Data 2fimages 2fwyjo6la4sdosj4n28crm 190419 s1 arfeen zain epithelial barriers
15:50
Epithelial Barriers
Data 2fimages 2fzvrbqxqqnmeftiqnspim 190419 s2 arfeen zain intracellular and extracellular pathogens
11:04
Intracellular and Extracellular Pathogens
Data 2fimages 2ffzctwcvls0uofpfxmgpu 190419 s3 arfeen zain viral invasion
10:52
Viral Invasion
Data 2fimages 2fgmwqg1m0qyinmo4abwss 190419 s4 arfeen zain bacterial and parasitic invasion
09:35
Bacterial and Parasitic Invasion

Lecture´s Description

Pathogen invasion is the prime emphasis of this sqadia.com medical V-learning lecture. Starting off with epithelial barriers, breaches in epithelial barrier, mechanism to overcome epithelial barriers, intracellular and extracellular pathogens also comes under debate. Then discussion continues on viral invasion in conjunction with bacterial and parasitic invasion.

Epithelial Barriers

Thick covering of skin protects human body from pathogen invasion. Breaches in epithelial barrier such as wounds gives direct access to pathogens. However, primary pathogens do not require wound to gain access. Moving onward, Zain Arfeen discusses epithelium colonizing pathogens. Also, mechanism to overcome epithelial barriers is conversed about.

Intracellular and Extracellular Pathogens

Mechanisms of extracellular pathogens disturb host cells without entering them. Next, Bordetella Pertussis comes under consideration. Enteropathogenic E. coli (EPEC) causes diarrhea in young children and uses type III secretion system rather than exerting its effect through toxins. Mechanisms of intracellular pathogens is also pursued in this section along with advantages of life inside host cell.

Viral Invasion

Viruses bind to surface receptors and the first virus receptor identified was E. coli surface protein t. Discussion continues on exploitation of cell surface receptors. Some viruses use more than one type for instance HIV-1 uses two types of receptors for entry i.e. primary receptor and co-receptor. Mode of entry of enveloped and non-enveloped viruses is also delineated later on.

Bacterial and Parasitic Invasion

Mechanisms of bacterial invasion is reported in the beginning of this section. Subsequently, zipper mechanism and trigger mechanism are elaborated through diagram. Intracellular eukaryotic parasites invade host cells through a variety of complex pathways. Moreover, comprehensive elucidation is given on Toxoplasma Gondii which protrudes an unusual microtubule-based structure called a conoid and facilitates entry into the host.

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