In this video lecture, educator describes how plasma is obtained from blood and its constituents. Hundreds of different proteins are present in plasma which have different characteristics. Electrophoresis separates plasma proteins into 5 bands.
Educator explained the starling hypothesis. Albumin is clinically very significant. α1-Antitrypsin inhibits trypsin, elastase, and collagenase & other proteolytic enzymes released during inflammation. α1-Antitrypsin deficiency produces hereditary disorder.
Thyroxine binding globulin is the major transport protein for thyroid hormone. Haptoglobin binds with ‘free’ hemoglobin. Ceruloplasmin transport protein. Alpha -2 Macroglobulin is major plasma proteinase inhibitor. Transferrin is an iron transport protein and is clinically very significant.
Low density lipoproteins transports cholesterol from the liver to the tissues of the body. High-density lipoprotein removes cholesterol from atheroma.
The complement system consists of several small proteins found in the circulating blood. Basic function of complement system is lysis of cells, opsonization for phagocytosis and immune clearance.
C-Reactive Proteins and fibrinogen are an acute phase reactant. Several proteins play role in immune system. There are five types of globulins and five classes of antibody.