Protein Translocation via ER

by Afridi, Maham

Cell Biology

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Data 2fimages 2fz0etnovnttcc7golt4jg 180928 s0 afridi maham protein translocation via er intro
07:35
Protein Translocation via ER
Data 2fimages 2fpti42vl1r4eif6txaucn 180928 s1 afridi maham er tail anchored proteins integration
18:17
ER Tail-Anchored Proteins Integration
Data 2fimages 2fvmd9g2usju0xxugpegeq 180928 s2 afridi maham glycosylation
18:29
Glycosylation
Data 2fimages 2fmnfrlzh0rlql5aernzlg 180928 s3 afridi maham fate of improperly folded proteins
12:28
Fate of Improperly Folded Proteins
Data 2fimages 2fws0yjkkcqaoqjp5rdkut 180928 s4 afridi maham misfolded proteins in er
11:29
Misfolded Proteins in ER
Data 2fimages 2fxpk317vctgcntrbdqr9u 180928 s5 afridi maham lipid bilayer assembly
16:48
Lipid Bilayer Assembly

Lecture´s Description

ER Tail-Anchored Proteins Integration
In this lecture ´´ Protein Translocation via ER ´´ is explained. Section one is about ´´ ER Tail-Anchored Proteins Integration´´. In the start of this lecture, translocated polypeptide chains are discussed. After that, protein disulphide isomerase (PDI) is introduced. Lastly, chaperone protein BiP is made a part of discussion.


Glycosylation
Section two is about “Glycosylation”. Initially, N- linked or asparagine linked glycosylation is explained. The educator then talks about oligosaccharide trimming or processing along with O-linked oligosaccharide glycosylation. Calnexin and calreticulin are also elucidated in this section. In the end, the educator explains how oligosaccharides are used as tags.


Fate of Improperly Folded Proteins
Section three is about ‘Fate of Improperly Folded Proteins“. This section is started with the explanation of retrotranslocation. The misfolded proteins are demonstrated and recognition of misfolded or unfolded proteins are thoroughly explained. Finishing this section, the educator talks about multiple translocator complexes.


Misfolded Proteins in ER
Section four is about ‘’ Misfolded Proteins in ER’’. Starting with the discussion on how misfolded proteins in ER signal to nucleus. Also, the activation of second transmembrane kinase is discussed in the end.


Lipid Bilayer Assembly
Section five is about “Lipid Bilayer Assembly’’. It discusses glycosylphosphatidylinositol anchor in the beginning. The educator then talks about how ER assembles lipid bilayers. Scrambalase and flippases are then elucidated.  After that, cholesterol and ceramide is explained. In the end of this lecture, transport vesicles network and phospholipid exchange proteins are demonstrated.

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