Systemic Autoimmune Diseases

by Dildar, Mahwish

Pathology

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8ibcepzfrnwrkbfy3jfl 180712 s0 dildar mahwish systemic autoimmune diseases intro
01:07
Systemic Autoimmune Diseases
Xzomnlpqtsm6le8hn4sz 180712 s1 dildar mahwish normal immune response
02:23
Normal Immune Response
Etoo9t9t16rempv4ormn 180712 s2 dildar mahwish hypersensitivity disorders
07:29
Hypersensitivity Disorders
6aqpufysgsk6kfpmpwkq 180712 s3 dildar mahwish autoimmune disorders
26:06
Autoimmune Disorders
Nii4xotftacufldqwzzg 180712 s4 dildar mahwish immunodeficiency syndromes
15:30
Immunodeficiency Syndromes
Qtminxkrrbs7snt7jqql 180712 s5 dildar mahwish amyloidosis and rejection of tissue transplant
10:23
Amyloidosis and Rejection of Tissue Transplant

Lecture´s Description

Normal Immune Response
In this lecture ´´Systemic Autoimmune Diseases´´ are explained. Section one is about ´´Normal Immune Response´´. At first educator gives the introduction to immune system and immunity. After that types of immunity are discussed. Innate Immunity is first type explained by the educator. Epithelial barriers are also considered. Next subject of discussion is acquired immunity. This include humoral immunity and cell-mediated/cellular immunity.


Hypersensitivity Disorders
Section two is about ‘’Hypersensitivity Disorders’’. Initially educator defines hypersensitivity disorders and its causes. Next is the elucidation of immediate hypersensitivity reaction. After that type - I hypersensitivity reaction is focused. This is followed by comprehensive discussion of type - II hypersensitivity reaction. After that type - III hypersensitivity reaction is also explained. In type - III hypersensitivity reaction educator’s prime focus is immune complex disease. Finally, in this section type - IV hypersensitivity reaction are pursued.


Autoimmune Disorders
Section three is about ‘’Autoimmune Disorders’’. Educator started this section by the explanation of autoimmune diseases. Next, discussion continues on different autoimmune diseases that are mediated by antibodies, mediated by T-cells, and postulated to be of autoimmune origin. This is followed by immunologic tolerance. After that mechanisms of autoimmunity are discussed. Then pathogenesis of autoimmunity is focused. Moving onward, a condition called systemic lupus erythematosus is explained.  In the next slide, its criteria for classification is pursued. Subsequently, pathogenesis of SLE comes under consideration. Moreover, antibodies are highlighted. After that mechanisms of tissue injury are focused. Then clinical manifestations are reported. Educator also tells the morphology of SLE. Next theme of discussion here is rheumatoid arthritis. This is followed by Sjogren syndrome. Afterwards, systemic sclerosis also known as scleroderma is explained. Pathogenesis of scleroderma is pursued likewise. Educator reveals information in detail on its morphology. Additionally, its clinical features are also reported. Concluding this section inflammatory myopathies are discussed. Finally, other disease such as mixed connective tissue disease, polyarteritis nodusa, and IgG4-related disease are reported.


Immunodeficiency Syndromes
Section four is about ‘’Immunodeficiency Syndromes’’. At first educator gives an introduction of immune deficiency disease. After that primary immune deficiency disease i.e. congenital is explained in detail along with its types. Following this Bruton disease is discussed. Next focus is the common variable immunodeficiency. Then hyper-IgM syndrome is explained. In the next slide DiGeorge syndrome is reported. Moreover, information is delivered about severe combined immunodeficiency. This is followed by the discussion of defects in lymphocyte activation. Afterwards, Wiskott-Aldrich syndrome is elucidated. Then genetic deficiencies are focused. Moreover, in this section secondary immune deficiency disease i.e. acquired are presented. Educator talks about acquired immunodeficiency syndrome (AIDS) in detail. Its mode of transmission is explained. AIDS; etiology and pathogenesis is illustrated comprehensively. Moving onward, abnormalities of immune function are reported. Natural history and clinical course is the next subject of discussion. Lastly, clinical features and morphology is elucidated.


Amyloidosis and Rejection of Tissue Transplant
Section five is about ‘’Amyloidosis and Rejection of Tissue Transplant’’. Initially, amyloidosis is explained along with its definition, causes and amyloid deposits. In the next few slides, amyloid proteins are pursued. Then pathogenesis is discussed. This is followed by the classification of amyloidosis. After that morphology is elucidated. Next subject of discussion is pattern of organ involvement. Educator also focuses on recognition and rejection of allograft. Afterwards, classification of rejection is illustrated. This include hyperacute rejection, acute rejection, and chronic rejection. All of these are discussed in succession.

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