In this video lecture, educator describes Thyroid Metabolic Hormones starting with the initial introduction of Thyroid Gland. Then Physiologic anatomy of thyroid gland is explained with the help of diagram with the heading of Synthesis and Secretion. A large glycoprotein molecule synthesized by ER and GA and secreted into the follicles. Thyroglobulin contains tyrosine amino acids that combine with iodine to form T3 and T4 hormones. Thyroid hormones are formed within the thyroglobulin molecule. Thyroxine and Triiodothyronine must be cleaved from the thyroglobulin molecule, and released as free hormones. Thyroxine and Triiodothyronine Are Bound to Plasma Proteins synthesized by liver mostly thyroxine-binding globulin and much less so with thyroxine-binding pre-albumin and albumin.
Physiologic Functions of Thyroid Hormone are the Transcription of Large Number of Genes and Increase Cellular Metabolic Activity, Effects on Growth and Effect on Specific Mechanisms. In the next section of lecture the educator describes the Regulation of Thyroid Hormone and Anti Thyroid Substances. In the last section of this lecture Diseases of Thyroid are explained which are Hyperthyroidism, Grave’s Disease, Exophthalmos, Endemic Goiter, Idiopathic Nontoxic Goiter, and Cretinism their causes, symptoms and treatments are explained in detail by educator.