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Lecture´s Description

Clopidogrel is an antiplatelet drug that is inactive and converted by cytochrome enzymes into active metabolite. Clopidogrel prevents binding of ADP to receptor by binding itself and cause activation of adenylyl cyclase which converts ATP to cAMP and phosphorylate vasodilator stimulated phosphoprotein. This phosphorylated form is unable to activate GP IIb/IIIa receptors, preventing the platelet aggregation.

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