This sqadia.com short video clip is a brief explanation of Infectious mononucleosis.
Infectious mononucleosis is cause by Epstein-Barr virus. In a susceptible sero-negative host, the virus in the contaminated saliva invades and replicates within epithelial cells of the salivary gland. It then enters B cells in the lymphoid tissues. Inside the lymph node, there are lymphoid follicles and antigens displayed on follicular dendritic cells. B cells migrate to edge of follicle where they contact effector CD4+ T cell. Activated B cells migrates back into the follicle and proliferate. These long-lived memory B cells serve as a lifelong reservoir for virus. Infection spread throughout the body by lymphatic system. Atypical lymphocytes are seen on histological examination.