Lower Gastrointestinal Cancers

Medicine

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Data 2fimages 2ffkfg5k7btooapa6wud80 190121 s0 mushtaq saima lower gastrointestinal cancers intro
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Lower Gastrointestinal Cancers
Data 2fimages 2f2vc7gy6kt4awvtbrkqwz 190121 s1 mushtaq saima colorectal cancer
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Colorectal Cancer
Data 2fimages 2foisaplxsdynq9yoky0xv 190121 s2 mushtaq saima risk factors
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Risk Factors
Data 2fimages 2ffcusdynvraqmg1wmvea1 190121 s3 mushtaq saima prevention and screening
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Prevention and Screening
Data 2fimages 2fifr7lslrn2yh04ojiixg 190121 s4 mushtaq saima staging and treatment
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Staging and Treatment
Data 2fimages 2fevoslzfirmcncgyj8mty 190121 s5 mushtaq saima cancers of the anus
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Cancers of the Anus

Lecture´s Description

A number of molecular changes are noted in adenomatous polyps and colorectal cancers. The developmental steps toward carcinogenesis include point mutations in the K-ras protooncogene, hypomethylation of DNA. Polyp conversion into cancer depends upon gross appearance of lesion. Polyposis coli is associated with a deletion in the long arm of chromosome 5 in both neoplastic and normal cells.

Hereditary nonpolyposis colon cancer (HNPCC), also known as Lynch’s syndrome, is another autosomal dominant trait. The most effective class of chemo preventive agents is aspirin and other NSAIDS. Screening strategies for colorectal cancer includes digital rectal examination, stool testing, endoscopy. The development of anal cancer is associated with infection by human papillomavirus.

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