Dr. Saima Mushtaq extensively elaborates subacute meningitis in this sqadia.com medical video lecture. In this V-learning lecture, common causative organisms and etiological factors are pursued initially. After that, information about how to carry out diagnosis through various test is delivered. Moreover, antimicrobials and syphilitic meningitis is also considered.
Unrelenting headache and stiff neck, lethargy, and cranial nerve abnormalities are some of the clinical manifestations of subacute meningitis. Common causative organisms include M. Tuberculosis, C. Neoformans, H. Capsulatum. Then comments are given on fungal infections which arises by inhalation of airborne fungal spores. Localized pulmonary fungal infection remains dormant in lungs.
At first, classic csf abnormalities are conversed about for laboratory diagnosis. PCR nucleic acid amplification tests are also carried out for diagnosis. Laboratory diagnosis of CSF abnormalities in fungal meningitis illustrates that there is increased protein concentration and decreased glucose concentration. Concluding comments are given on cryptococcal polysaccharide antigen test.
Empirical therapy of tuberculous meningitis is prescribed on the basis of high suspicion index. Meningitis due to C. neoformans can be treated with induction therapy which includes the use of amphotericin B and flucytosine for at least 4 weeks. Meningitis due to H. capsulatum can be treated with AmB. High-dose fluconazole as monotherapy is given for the treatment of C. immitis meningitis.
A complication of untreated syphilis that involves inflammation of the tissues covering the brain and spinal cord in known as syphilitic meningitis. Symptoms include vision changes, nausea, pain and stiffness in the neck and shoulders. Reactive serum treponemal test and microhemagglutination assay is carried out for diagnosis of syphilitic meningitis. Information about treatment is given at last.